Jornal de Neurologia e Neurociência

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Activity of serum Cathepsin D in Alzheimer's disease

Manuel Menendez Gonzalez, Ana Suarez , Patricia Lopez, Maria Teresa Calatayud Noguera, Marta Martinez Rivera, Renee Ribacoba, Alfonso Lopez Muniz

Growing evidence support the hypothesis that cathepsin D (catD) is related to AD but the activity of serum catD had never been assessed inpatients with dementia. We studied the activity of serum catD in different stages of AD as well as in patients with Mild Cognitive Impairment(MCI) and Vascular Dementia (VD). Results do not support catD activity as a useful biomarker for dementias since we found no significantdifferences between AD stages or between AD and MCI or VD. Surprisingly we found a relation between ApoE genotype, gender and catDactivity that reaffirm the possibility that catD might be involved in the pathogenesis of AD specifically in men carriers of ApoE4.