Translational Biomedicine

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Abstrato

Advances in Clinical Translational and Translational Research in Neurosciences

Sarah Horn

People who have a history of exposure to early life stressors such abuse, domestic violence, and parent psychopathology are more likely to use drugs and become addicted to them. ELS-exposed children are frequently underserved by evidence-based programmes, which is unfortunate because current interventions have mixed efficacy at improving outcome trajectories for these children. Here, we use a translational neuroscience paradigm to outline how neuroscience might improve our comprehension of changes in children's function associated with ELS and guide the creation of more focused, successful early intervention and addiction prevention programmes. Across the areas of sensory, emotional, motivational, and executive function, potential neural pathways affected by ELS and connected to addiction are described. Then, we give an example of how translational neuroscience ideas were used to a group of early interventions.