Suparna Roy* and P Anantharaman
Seaweeds such as Ulva lactuca, Ulva fasciata, Caulerpa racemosa, Caulerpa lentillifera, Gracilaria corticata and Gracilaria dura were analysed for its in-vitro anti-cholesterol activity. After investigation, Ulva fasciata showed highest in-vitro anti-cholesterol activity of 97.63 %, so Ulva fasciata were further analysed for in-vivo anti-hypercholesterolemic activity by experimenting on Wistar albino rats. The serum total lipid profiles of treated rats were analyzed. The concentration of HDL is comparatively high in all groups. The concentration of LDL and Triglyceride is lowering subsequently in all the groups except the hypercholesterolemic group. The optimum lowering of LDL, TC and increase of HDL were observed for the group-IV of Wistar albino rats which were treated with 600 mg Ulva fasciata. The histopathological analysis of tissues of heart, liver, kidney and brain showed major inflammation and necrosis of tissues of the group-II rats which was treated with high fat died and seaweed treated rats showed no evidence of tissue inflammation and necrosis.
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