Translational Biomedicine

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Covid-19, Stress, and Brain Morphometry by Translational Psychiatry

Martijn Parra

With the COVID-19 epidemic has come a nearly unheard-of worldwide health calamity. Considering both the direct impacts of the illness, such as the development of psychopathology or psychiatric disorders in COVID-19-affected people, as well as the indirect repercussions associated to forced and self-imposed seclusion, this health crisis is also a mental health problem. In large-scale retrospective analyses, psychiatric disorders like anxiety and insomnia have been reported at higher rates in people with a COVID-19 diagnosis compared to either influenza or other health problems, and it has been demonstrated that having psychiatric disorders before COVID-19 infection carries a higher relative risk of COVID-19 diagnosis. However, the COVID-19 pandemic's effects on mental health go well beyond the effects of infection and the short- or long-term impacts they may have on COVID-19 survivors. In fact, measures of isolation that are imposed by an individual, a group, or the government, such as "lockdowns" and other restrictions on social interaction, have been examined for their effects on a variety of mental health outcomes in the general population, not just COVID-19 survivors.

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