Yanting Li*
For the administration and release of medicinal and imaging substances, numerous nanocarriers with different compositions and geometries have been produced. In order to achieve sustained release, many mechanisms like ion pairing and hydrophobic interaction need to be investigated due to the high specific surface areas of nanocarriers. Recently, we created a three-parameter model that takes into account first-order drug release from liposomes and reversible drug-carrier interaction. The analytical problem was solved in closed form. Here, we further investigate the model's capacity to represent the release of bioactive compounds from diverse nanocarriers, including medicines and growth factors. The model may be shown to be capable of mimicking the main types of drug release kinetics through a parameter research. More than 60 sets of experimental data from different drug delivery methods, including nanoparticles, hollow particles, fibers, and hollow fibers, were further fitted using the model. Additionally, bootstrapping is utilised in some circumstances to validate the model and assess the precision of parameter estimation. The model is practical for the design and development of novel drug delivery systems due to its simplicity, universality, and the physical clarity of each model parameter.
KeywordsNanotechnology; Nanocarriers; Drug delivery; Drug targeting; Drug-carrier interaction
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