English Spanish Chinese Russian German French Japanese Hindi Telugu Tamil

Jornal Internacional de Desenvolvimento e Pesquisa de Drogas

  • ISSN: 0975-9344
  • Índice h do diário: 44
  • Pontuação de citação de diário: 59.93
  • Fator de impacto do periódico: 48.80
Indexado em
  • Genamics JournalSeek
  • Infraestrutura Nacional de Conhecimento da China (CNKI)
  • CiteFactor
  • Scimago
  • Diretório de Indexação de Periódicos de Pesquisa (DRJI)
  • OCLC- WorldCat
  • publons
  • MIAR
  • Comissão de Bolsas Universitárias
  • Euro Pub
  • Google Scholar
  • SHERPA ROMEU
  • Laboratórios secretos do mecanismo de pesquisa
  • ResearchGate
Veja mais
Compartilhe esta página

Abstrato

Effects of Coenzyme Q10 on Biochemical Markers of Hepatic Necroinflammation in Patients with Nonalcoholic Fatty Liver

Sara Shafieipour, Ali Bahari, Mohammad Hashemi and Noorollah Hashemzehi

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common metabolic liver disorder that can progress to cirrhosis. Up to now, there is no established treatment for this disease. Methods: We randomly assigned 55 adults with NAFLD to receive Coenzyme Q10 (CoQ10) 60 mg daily (30 subjects) or vitamin E 800 unit daily (25 subjects) for 3 months to assess the effect of CoQ10 versus vitamin E on BMI, ALT, AST, ALK-P, PT, Bilirubine, ALB, Ferritin, TG, Total Cholestrol, FBS, Serum Insuline, LDL, HDL, Total Anti Oxidant Capacity (TAC) before and after intervention. Results: In CoQ10 group there was a significant improvement in AST, ALT, TAC (P value<0.0001), Ferritin, Total bilirubin, GGT (p value<0.01), HDL (p value<0.05). In vitamin E group there was a significant improvement in AST, ALT, TAC, Ferritin, GGT, HDL (p value<0.01). There was not significant improvement in FBS, Insulin resistance and other lipid profile in both groups. Conclusion: Our study assigned that 60 mg CoQ10 is effective on improvement of noninvasive liver parameters in NAFLD. We suggest longer duration treatment and with larger dosage. We also suggest a large study with biopsy control for the assessment the effect of CoQ10 in NAFLD.