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Jornal Internacional de Desenvolvimento e Pesquisa de Drogas

  • ISSN: 0975-9344
  • Índice h do diário: 44
  • Pontuação de citação de diário: 59.93
  • Fator de impacto do periódico: 48.80
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Abstrato

Marine Halophyte: An Inviolated and Promising Source of Novel Lead Compounds against Deadly Diseases like Dengue and Breast Cancer

Samuel P, Vijayakumar J, Sudarmani DNP, Rajeswari P, Amirtharaj K and Deenathayalan R

The present study was started with an intention to unveil the potentials of marine halophyte Salicornia europaea abundant in south east coast of Tamilnadu. To study the metabolite, profile the shade dried biomass of the halophyte was extracted with methanol and ethyl acetate and the fractions showed 29 and 32 lead molecules respectively. The drug targets against dengue virus protein NS5 and Estrogen Receptor (ER) protein for breast cancer were retrieved from PDB and docked with selective lead molecules of solvent fractions with the help of Hex 6.3. E-min/E-max values for the tested lead molecules against the corresponding drug targets were calculated. Significant results have been obtained and suggest that this unexploited halophyte could be exploited to harvest promising lead molecules.