Jornal de Neurologia e Neurociência

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Neuroprotective Effect of EDR Peptide in Mouse Model of Huntington's Disease

Vladimir Khavinson, Natalya Linkova, Ekaterina Kukanova, Anastasiya Bolshakova, Anastasiya Gainullina, Solomon Tendler, Ekaterina Morozova, Svetlana Tarnovskaya, Deby Susanti Pada Vinski, Vladimir Bakulev and Nina Kasyanenko

Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder. The study in functioning and aging of neurons may give an opportunity to regulate these processes. Previous investigations demonstrated the ability of EDR peptide (Glu-Asp-Arg) to penetrate a cell nucleus and stimulate gene expression. The data obtained prompt EDR peptide capability to restore the morphology of spines in striatum neurons in Huntington’s disease (HD) mouse model. EDR peptide has been shown by us to bind the DNA in solution (absorption spectroscopy and dynamic light scattering) and in a computer model. The proposed model suggests that EDR peptide binds specific binding site oligo (dCG) along the DNA minor groove.