Enzimologia Molecular e Alvos de Drogas

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Abstrato

Polyphenol Flavonoid stimulates immune responses by increasing IFN- and IL-2 secretion in primary cultured lymphocytes

Priyam Garg

Astaxanthin, a strong cell reinforcement carotenoid, assumes a significant part in balancing the safe reaction. In this review, we analysed the immunomodulatory impacts of astaxanthin on cytokine creation in essential refined lymphocytes both in vitro and ex vivo. Direct organization of astaxanthin (70-300 NM) didn't create cytotoxicity in lipopolysaccharide (LPS, 100 µg/mL)- or concanavalin A (Con A, 10 µg/mL)- enacted lymphocytes, though astaxanthin alone at 300 nM prompted expansion of splenic lymphocytes (p < 0.05) in vitro. In spite of the fact that astaxanthin, alone or with Con A, meaningfully affected interferon (INF-γ) and interleukin (IL-2) creation in essential refined lymphocytes, it upgraded LPSprompted INF-γ creation. In an ex vivo try, oral organization of astaxanthin (0.28, 1.4 and 7 mg/kg/day) for 14 days didn't cause modifications in the body or spleen loads of mice and furthermore was not poisonous to lymphocyte cells got from the mice.

Keywords

Astaxanthin; LPS; Con A; Mice; Lymphocytes; INF-γ; IL-2; Immunomodulation