Priorities of Clinical Genetics in Translational Biomedicine

In order to understand the promise of personalized medicine, Translational Bioinformatics (TBI) research will get to still address implementation issues across the clinical spectrum. Here we present the state-of-the-art of clinical implementation of TBI-based tools and resources. Open areas of clinically-relevant TBI research identified during this review include developing data standards and best practices, publicly available resources, integrative systemslevel approaches, user-friendly tools for clinical support, cloud computing solutions, emerging technologies and means to deal with pressing legal, ethical and social issues.