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Arquivos de Medicina

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The importance of neopterin in COVID-19: the prognostic value and relation with the disease severity

Kevser Kubra Kırboga, Yousef Rasmi, Nadia Heidari, Shima Hatamkhani, Burcu Tekin, Shahryar, Alipour, Roya Naderi, Yeghaneh Farnamian and Ilknur Akca

Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-] gamma, is an important cytokine in the antiviral immune response. NPT has been used as a marker for early assessment of disease severity in different of diseases. The main cause of NPT production is the proinflammatory cytokine IFN. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARSCoV- 2 and suggest that targeting of NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.