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Updated Review on Proniosomal Transdermal Drug Delivery System

Dr. Ram Babu Sharma*, Deepak Kashyap, Hitesh Thakur

Scientists worked to stabilise without having an impact on the noisome drug delivery method its marital characteristics, which led to the creation of the potential drug carrier proniosome. Drug delivery methods using niosomes and liposomes have disadvantages that proniosomes do not. Dry formulations of a non-ionic, water-soluble surfactant are called proniosomes and are applied to a carrier system. Proniosome hydration results in the formation of niosomes.

They have the potential to increase the dissolution, accessibility, and uptake of various medications by addressing the instability issues with niosomes and liposomes. In addition, they provide a flexible method of drug delivery for a variety of both hydrophilic and hydrophobic medicines. They can deliver medications using a number of techniques to the intended site of action, offering a controlled drug release of the medication and a reduction in any potentially harmful side effects. It's critical to be knowledgeable of each study's limitations, which each have their own benefits and drawbacks, in order to get the right study results. Ecological, prospective, retrospective, case-control, case-crossover, or crosssectional cohort designs are all possible for observational studies. A vital subclass of observational experiments of the diagnosis research designs, which compare the accuracy of different diagnostic approaches and tests to other diagnostic measures, can be used to derive important findings. Only data collected utilising a valid scientific methodology and the appropriate statistical methods can be used in biomedical research to draw meaningful findings. As a result, it's critical to pick a solid study strategy in order to offer a just and impartial evaluation of the research concerns. This review focuses on a variety of proniosome-related topics including - advantages, preparation, mechanism of action, materials and their specification, study design, characterization &evaluation parameter.

Proniosomes; Niosomal; Factorial designs; Relationship; TDS