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Anais de Pesquisa Clínica e Laboratorial

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Abstrato

The Expression and Effect of Helper IL-10- Producing B Cells in Human Minimal Change Nephrotic Syndrome

Li Zhang, Xiguang Sun, Shengguo Zhou, Rebecca Crew, Man Li, Mingyuan Liu and Yanfang Jiang

This study is aimed at determining the putative contribution of B cell types in patients with newly diagnosed minimal change nephrotic syndrome (MCNS) before treatment and 8-12 weeks post-treatment. Significantly higher percentages of CD19+CD27+, CD19+CD38+, and CD19+CD86+ B cells were observed compared to healthy controls. Importantly, lower levels of Breg cells and intracellular expression of IL-10 protein were detected in MCNS patients. 24-h urinary proteins were positively correlated with the percentage of CD19+CD27+ B cells and negatively correlated with the percentage of Breg cells. A positive correlation between the percentage of CD19+CD5+CD1d+ cells and the levels of serum albumin was observed in these patients. Treatment with prednisone (PDN) significantly reduced the frequency of CD19+CD27+, CD19+CD38+, and CD19+CD86+ B cells, and elevated the levels of Breg cells and Breg cell-derived IL-10. This data indicates that several of the CD19+ B cell subtypes and IL-10+ Breg cells have a potentially crucial role in the MCNS patients.